Regulatory

Part:BBa_K4829005:Design

Designed by: Modernatx   Group: iGEM23_IISc-Bengaluru   (2023-10-04)


3' UTR patented by Modernatx


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

This part was NOT designed by us. More information may be available on the US patent page US10925935B2. However, what follows is a brief summary of the design present

  • The 110-nt 3’-UTR of human β-globin gene (HBA1) placed between the last stop codon and the Poly(A) tail.


Source

It was derived from Beta globin UTRs of humans. More information may be available on the US patent page US10925935B2.

References

Javier T. Granados-Riveron, Guillermo Aquino-Jarquin, Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-2,Biomedicine & Pharmacotherapy,Volume 142,2021,111953,ISSN 0753-3322,https://doi.org/10.1016/j.biopha.2021.111953.